Health Scientists have made an important leap on the path to the creation a HIV vaccine

02:34  11 july  2018
02:34  11 july  2018 Source:   businessinsider.com.au

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Researchers have made an important breakthrough in work to develop a vaccine to protect against HIV . Most attempts have failed because the virus is able to rapidly mutate, making most vaccines ineffective. However, scientists in the US have created a vaccine that has managed to get to the

Researchers have made an important breakthrough in work to develop a vaccine to protect against HIV . Most attempts have failed because the virus is able to rapidly mutate, making most vaccines ineffective. However, scientists in the US have created a vaccine that has managed to get to the

  Scientists have made an important leap on the path to the creation a HIV vaccine © Provided by Business Insider Inc

Researchers have made an important breakthrough in work to develop a vaccine to protect against HIV.

Most attempts have failed because the virus is able to rapidly mutate, making most vaccines ineffective.

However, scientists in the US have created a vaccine that has managed to get to the first step, with almost 400 healthy uninfected adults mounting an immune response to the vaccine.

The trial recruited 393 HIV-uninfected adults aged 18 to 50 from clinics in east Africa, South Africa, Thailand and the US.

The Mosaic HIV vaccine is one of only five experimental vaccines to make it this far since the HIV/AIDS epidemic began.

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Since then, new therapies like antiretroviral drugs have made HIV infection into something it’s possible to live with rather than die from—at least, in the developed world. The search for a vaccine continues, a decadal, tidal ebb and flow of optimism followed by failure.

Though scientists have been able to create vaccines for other viruses , developing a vaccine for HIV has been especially challenging. So why are HIV vaccines so elusive? HIV behaves unlike most other viruses in some important ways.

But it remains to be seen whether the vaccine will make it past the next step when it will be given to 2600 at risk women in Southern Africa.

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After years of disappointment, researchers have finally found a potential basis for an HIV vaccine . Scientists at the National Institute of Allergy and Infectious Diseases say they have discovered three human antibodies that neutralize more than 90 percent of the current circulating HIV -1 strains.

Scientists believe that they have made a 1) _ breakthrough in fighting HIV - they have shown what happens when an One protein that sticks out from the surface of the virus and binds to receptors on host cells is one such region, which makes it a target for vaccine development.

The research published in the journal The Lancet shows that the experimental vaccine generated robust immune responses.

“These results represent an important milestone," says Professor Dan Barouch, Professor of Medicine at Harvard Medical School, who led the study.

“These results should be interpreted cautiously.

"The challenges in the development of an HIV vaccine are unprecedented, and the ability to induce HIV-specific immune responses does not necessarily indicate that a vaccine will protect humans from HIV infection."

Almost 37 million people worldwide are living with HIV/AIDS, with an estimated 1.8 million new cases every year.

In the 35 years of the HIV epidemic, only four HIV vaccine concepts have been tested in humans, and only one has provided evidence of protection.

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